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Glycerol 1-phosphate
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・ Glycerol-1-phosphatase


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Glycerol 1-phosphate : ウィキペディア英語版
Glycerol 1-phosphate

''sn''-Glycerol 1-phosphate〔This article uses stereospecific numbering where stereoconfiguration is not explicitly specified.〕 is a phosphoric ester of glycerol, which is a component of archea-specific ether lipids. Equally appropriate names in biochemical context include glycero-1-phosphate, 1-''O''-phosphonoglycerol, and 1-phosphoglycerol.〔(【引用サイトリンク】title=Nomenclature of Phosphorus-Containing Compounds of Biochemical Importance )〕 From a historical reason, it is also known as -glycerol 1-phosphate, -glycerol 3-phosphate, and -α-glycerophosphoric acid.〔
== Biosynthesis and metabolism ==
Glycerol 1-phosphate is synthesized by reducing dihydroxyacetone phosphate (DHAP), a glycolysis intermediate, with ''sn''-glycerol-1-phosphate dehydrogenase. DHAP and thus glycerol 1-phosphate is also possible to be synthesized from amino acids and citric acid cycle intermediates via glyconeogenesis pathway.
: + NAD(P)H + H+ → + NAD(P)+
Glycerol 1-phosphate is a starting material for ''de novo'' synthesis of archea-specific ether lipids, such as archaeol and caldarchaeol. It is first geranylgeranylated on its ''sn''-3 position by a cytosolic enzyme, phosphoglycerol geranylgeranyltransferase, and another geranylgeranyl group is then added on the ''sn''-2 position making unsaturated archaetidic acid, which is a key compound for synthesizing archeal lipids.
: + GGPPgeranylgeranylglycerol phosphate + PPi

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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