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''sn''-Glycerol 1-phosphate〔This article uses stereospecific numbering where stereoconfiguration is not explicitly specified.〕 is a phosphoric ester of glycerol, which is a component of archea-specific ether lipids. Equally appropriate names in biochemical context include glycero-1-phosphate, 1-''O''-phosphonoglycerol, and 1-phosphoglycerol.〔(【引用サイトリンク】title=Nomenclature of Phosphorus-Containing Compounds of Biochemical Importance )〕 From a historical reason, it is also known as -glycerol 1-phosphate, -glycerol 3-phosphate, and -α-glycerophosphoric acid.〔 == Biosynthesis and metabolism == Glycerol 1-phosphate is synthesized by reducing dihydroxyacetone phosphate (DHAP), a glycolysis intermediate, with ''sn''-glycerol-1-phosphate dehydrogenase. DHAP and thus glycerol 1-phosphate is also possible to be synthesized from amino acids and citric acid cycle intermediates via glyconeogenesis pathway. : + NAD(P)H + H+ → + NAD(P)+ Glycerol 1-phosphate is a starting material for ''de novo'' synthesis of archea-specific ether lipids, such as archaeol and caldarchaeol. It is first geranylgeranylated on its ''sn''-3 position by a cytosolic enzyme, phosphoglycerol geranylgeranyltransferase, and another geranylgeranyl group is then added on the ''sn''-2 position making unsaturated archaetidic acid, which is a key compound for synthesizing archeal lipids. : + GGPP → geranylgeranylglycerol phosphate + PPi 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Glycerol 1-phosphate」の詳細全文を読む スポンサード リンク
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